Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality

Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality

Blog Article

Increasing evidence has cast doubt over the HDL-cholesterol hypothesis.The complexity of the HDL particle and its rashguard proven susceptibility to remodel has paved the way for intense molecular investigation.This state-of-the-art review discusses the molecular changes in HDL particles that help to explain the failure of large clinical trials intending to interfere with HDL metabolism, and details the chemical modifications and compositional changes in HDL-forming components, as well as miRNA cargo, that render HDL particles ineffective.Finally, the paper discusses the challenges that need to be overcome Seat Post Ring to shed a light of hope on HDL-targeted approaches.